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Article

CRUMBS-associated mutations in Retinitis Pigmentosa and its impact on molecular scaffolding.

Biochimica et biophysica acta. Proteins and proteomics - 1 Jul 2026

Khan Sumbul, Siddique Yasir Hasan

Abstract excerpt

The death of photoreceptors is a primary driver of retinal degenerative diseases, leading to irreversible vision loss. In Retinitis Pigmentosa (RP), a wide spectrum of mutations has been identified. Among these, the Crumbs (CRB) family of proteins, comprising CRB1, CRB2, and CRB3, plays a critical role in maintaining retinal homeostasis. The distribution of CRB mutations indicates population-specific variations,...

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Source

Identifiers

PMID: 42107829
DOI: 10.1016/j.bbapap.2026.141147

Genes

CRB1
CRB2
CRB3
EGF
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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