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Article

Lack of association between EPHX1 polymorphism and esophageal cancer risk: evidence from meta-analysis.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus - 1 Jan 2000

Yan Y L, Chen X, Liang H J, Wang J, Li T J, Li R L, Li S, Qin X

Abstract excerpt

The microsomal epoxide hydrolase 1 (EPHX1) Tyr113His and His139Arg polymorphisms have been reported to be associated with esophageal cancer (EC) risk, yet the results of these previous results have been inconsistent or controversial. The objective of this study was to explore whether the EPHX1 Tyr113His and His139Arg polymorphisms confer risk to EC. The relevant studies were identified through a search of PubMed,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25714851
DOI: 10.1111/dote.12169

Genes

EPHX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lack of association between EPHX1 polymorphism and esophageal cancer risk: evidence from meta-analysis.PMID 25714851Read ↗

Association between esophageal cancer risk and EPHX1 polymorphisms: a meta-analysis.Semantic proximity Read ↗

Meta-analysis demonstrates lack of an association of microsomal epoxide hydrolase 1 polymorphisms with esophageal cancer risk.Semantic proximity Read ↗

Association between microsomal epoxide hydrolase 1 polymorphisms and susceptibility to esophageal cancer: a meta-analysis.Semantic proximity Read ↗

EPHX1 Tyr113His and His139Arg polymorphisms in esophageal cancer risk: a meta-analysis.Semantic proximity Read ↗

Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer.Semantic proximity Read ↗

Systematic review and meta-analysis of the relationship between EPHX1 polymorphisms and colorectal cancer risk.Semantic proximity Read ↗

EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.Semantic proximity Read ↗

Quantitative assessment of the influence of EPHX1 gene polymorphisms and cancer risk: a meta-analysis with 94,213 subjects.Semantic proximity Read ↗

Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer.Semantic proximity Read ↗

Role of epoxide hydrolase 1 gene polymorphisms in esophageal cancer in a high-risk area in India.Semantic proximity Read ↗

Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China.Semantic proximity Read ↗

Putative EPHX1 enzyme activity is related with risk of lung and upper aerodigestive tract cancers: a comprehensive meta-analysis.Semantic proximity Read ↗

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