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Article

Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster.

The Journal of biological chemistry - 22 Oct 2010

Binz Tina M, Maffioli Sonia I, Sosio Margherita, Donadio Stefano, Müller Rolf

Abstract excerpt

The GE81112 tetrapeptides (1-3) represent a structurally unique class of antibiotics, acting as specific inhibitors of prokaryotic protein synthesis. Here we report the cloning and sequencing of the GE81112 biosynthetic gene cluster from Streptomyces sp. L-49973 and the development of a genetic m...

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Identifiers

PMID: 20710026
DOI: 10.1074/jbc.M110.146803
PMCID: PMC2963348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20710026-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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