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Article

Haplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent.

BMC cancer - 10 Apr 2008

Cavallone Luca, Arcand Suzanna L, Maugard Christine, Ghadirian Parviz, Mes-Masson Anne-Marie, Provencher Diane, Tonin Patricia N

Abstract excerpt

BACKGROUND: The TP53 polymorphisms Arg72Pro (Ex4+199 G>C) and Ins16 (IVS3+24 ins16) have been proposed to modify risk of breast cancer associated with germline BRCA1 and BRCA2 mutations. Allele frequencies of these polymorphisms were investigated to determine if they modify risk in BRCA mutation carriers in breast cancer cases drawn from French Canadian cancer families, a population shown to exhibit strong...

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Identifiers

PMID: 18402691
DOI: 10.1186/1471-2407-8-96
PMCID: PMC2329651

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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