Article
The p53 Arg72Pro and Ins16bp polymorphisms and their haplotypes are not associated with breast cancer risk in BRCA-mutation negative familial cases.
Cancer detection and prevention - 1 Jan 2008
De Vecchi Giovanna, Verderio Paolo, Pizzamiglio Sara, Manoukian Siranoush, Bernard Loris, Pensotti Valeria, Volorio Sara, Ravagnani Fernando, Radice Paolo, Peterlongo Paolo
Abstract excerpt
BACKGROUND: Germline disease-causing mutations in BRCA1 and BRCA2 genes confer high risk of breast and ovarian cancer, but account approximately for only 15% of familial cases. Theoretical models and experimental observations have indicated that the remaining familial aggregations would be explained by low-penetrance alleles. Moreover, alleles acting as genetic modifiers would modulate the breast cancer risk in...
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