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Extracellular Adenosine 5′-Triphosphate Alters Motility and Improves the Fertilizing Capability of Mouse Sperm1

10 Apr 2008

Abstract excerpt

Extracellular adenosine 5'-triphosphate (ATPe) treatment of human sperm has been implicated in improving in vitro fertilization (IVF) results. We used the mouse model to investigate mechanisms of action of ATPe on sperm. ATPe treatment significantly enhanced IVF success as indicated by both rate of pronuclear formation and percentage cleavage to the 2-cell stage. However, ATPe did not increase the percentage of...

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PMID: 18401012
DOI: 10.1095/biolreprod.107.065565

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