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The Role of the Iron Transporter ABCB7 in Refractory Anemia with Ring Sideroblasts

8 Apr 2008

Abstract excerpt

Refractory Anemia with Ring Sideroblasts (RARS) is an acquired myelodysplastic syndrome (MDS) characterized by an excess iron accumulation in the mitochondria of erythroblasts. The pathogenesis of RARS and the cause of this unusual pattern of iron deposition remain unknown. We considered that the inherited X-linked sideroblastic anemia with ataxia (XLSA/A) might be informative for the acquired disorder, RARS....

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PMID: 18398482
DOI: 10.1371/journal.pone.0001970

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