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Mitochondrial Iron Metabolism and Sideroblastic Anemia

1 Jan 2009

Abstract excerpt

Sideroblastic anemias are a heterogeneous group of disorders, characterized by mitochondrial iron overload in developing red blood cells. The unifying characteristic of all sideroblastic anemias is the ring sideroblast, which is a pathological erythroid precursor containing excessive deposits of non-heme iron in mitochondria with perinuclear distribution creating a ring appearance. Sideroblastic anemias may be...

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PMID: 19907149
DOI: 10.1159/000243796

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