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Article

Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins.

Cell stem cell - 10 Apr 2008

Chen Guibin, Ye Zhaohui, Yu Xiaobing, Zou Jizhong, Mali Prashant, Brodsky Robert A, Cheng Linzhao

Abstract excerpt

Pluripotent human embryonic stem (hES) cells can differentiate into various cell types derived from the three embryonic germ layers and extraembryonic tissues such as trophoblasts. The mechanisms governing lineage choices of hES cells are largely unknown. Here, we report that we established two i...

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Identifiers

PMID: 18397754
DOI: 10.1016/j.stem.2008.02.004
PMCID: PMC2442565

Genes

GPI
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18397754-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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