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An Improved Two‐Step Protocol for Trophoblast Differentiation of Human Pluripotent Stem Cells

2 Aug 2019

Abstract excerpt

Abstract We previously established a two‐step protocol for differentiation of human pluripotent stem cells (hPSCs) into trophoblasts, using a StemPro‐based minimal medium (EMIM) with bone morphogenetic protein‐4 (BMP4). This protocol was suboptimal, resulting in induction of mixed mesoderm and trophoblast markers. Furthermore, adapting hPSCs to StemPro has proven difficult, and prolonged culture in this medium...

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PMID: 31479595
DOI: 10.1002/cpsc.96

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