RNA-sequencing Strain-specific Genome Alignment Increases Differential Expression Findings in Comparison of C57BL/6J and DBA/2J Nucleus Accumbens

Abstract excerpt

Alcohol Use Disorder (AUD) is a polygenic disease defined by the inability to regulate alcohol consumption despite adverse consequences. C57BL/6J (B6) and DBA/2J (D2) mice, the progenitor strains to the BXD recombinant inbred strain, exhibit differences in voluntary ethanol consumption and other ethanol behaviors, making them frequently used models for studying genetic influences on ethanol responses. The B6 genom...

Topics

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• Corpus Striatum
• Gene Expression
• Gene Expression Profiling
• High-Throughput Nucleotide Sequencing
• Mice, Inbred C57BL
• Mice, Inbred DBA
• Oligonucleotide Array Sequence Analysis
• Sequence Analysis, RNA

Identifiers and source

Literature Corpus work

209a8c63-1488-5b62-ae2c-156a8627b5d4

DOI

10.1101/2025.05.25.656014