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Article

A dual-labeling method to quantify unscheduled DNA synthesis in primary cells.

Journal of pharmacological and toxicological methods - 1 Jan 2000

Li Weiwei, Choy David F, Post Joseph M, Sullivan Mark E

Abstract excerpt

Unscheduled DNA synthesis (UDS) has been used as an endpoint for measuring DNA damage in vitro and in vivo. Determination of UDS is regarded as a reliable genotoxicity assay by regulatory agencies including US FDA and EPA. In this study, we have developed an improved UDS assay to detect DNA damage and repair processes upon chemical exposure. We utilized a dual-labeling procedure in which fluorescent DAPI stained...

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Identifiers

PMID: 18396065
DOI: 10.1016/j.vascn.2007.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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