Aging mouse hearts are refractory to infarct size reduction with post-conditioning.

doi:10.1016/j.jacc.2007.11.070

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Article

Aging mouse hearts are refractory to infarct size reduction with post-conditioning.

Journal of the American College of Cardiology - 8 Apr 2008

Przyklenk Karin, Maynard Michelle, Darling Chad E, Whittaker Peter

Abstract excerpt

OBJECTIVES: Our aim was to establish whether the efficacy of post-conditioning is maintained in aging hearts. BACKGROUND: Post-conditioning, or relief of myocardial ischemia in a stuttered manner, has been shown to reduce infarct size, in part because of up-regulation of survival kinases (extracellular-signal regulated kinase [ERK] 1/2 or PI3-kinase/Akt) during the early min of reperfusion. All of these data...

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Identifiers

PMID: 18387442
DOI: 10.1016/j.jacc.2007.11.070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.