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Article

Non-angiogenic FGF-2 protects the ischemic heart from injury, in the presence or absence of reperfusion.

Cardiovascular research - 1 Apr 2004

Jiang Zhi-Sheng, Srisakuldee Wattamon, Soulet Fabienne, Bouche Gerard, Kardami Elissavet

Abstract excerpt

OBJECTIVE: Fibroblast growth factor-2 (FGF-2), given during ischemia or during reperfusion of the ischemic heart is cardioprotective, but its mitogenic activity may limit possible clinical applications. We have tested the cardioprotective potential of a non-mitogenic FGF-2 mutant (S117A) that no longer activates casein kinase 2 (CK2) in both acute and long-term studies. METHODS AND RESULTS: To test effects during...

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Identifiers

PMID: 15023562
DOI: 10.1016/j.cardiores.2004.01.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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