Article
Non-angiogenic FGF-2 protects the ischemic heart from injury, in the presence or absence of reperfusion.
Cardiovascular research - 1 Apr 2004
Jiang Zhi-Sheng, Srisakuldee Wattamon, Soulet Fabienne, Bouche Gerard, Kardami Elissavet
Abstract excerpt
OBJECTIVE: Fibroblast growth factor-2 (FGF-2), given during ischemia or during reperfusion of the ischemic heart is cardioprotective, but its mitogenic activity may limit possible clinical applications. We have tested the cardioprotective potential of a non-mitogenic FGF-2 mutant (S117A) that no...
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