Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonsteroidal anti-inflammatory drugs upregulate function of wild-type and mutant CFTR.

The European respiratory journal - 1 Aug 2008

Li J, Xiang Y-Y, Ye L, Tsui L-C, Macdonald J F, Hu J, Lu W-Y

Abstract excerpt

Small-scale clinical trials show that treatment of cystic fibrosis (CF) patients with ibuprofen, a nonsteroidal anti-inflammatory drug, improves the symptoms of CF and slows down the decline of lung function. Paradoxically, ibuprofen inhibits ligand-stimulated CF transmembrance conductance regulator (CFTR) activity. The aim of the present study was to investigate the effects of ibuprofen on CFTR function under...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Epithelium

Share to Patch-Clamp Techniques

Share to Receptors, GABA

Source

Identifiers

PMID: 18385167
DOI: 10.1183/09031936.00168007

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nonsteroidal anti-inflammatory drugs upregulate function of wild-type and mutant CFTR.PMID 18385167Read ↗

Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.Semantic proximity Read ↗

Activation of wild-type and deltaF508-CFTR by phosphodiesterase inhibitors through cAMP-dependent and -independent mechanisms.Semantic proximity Read ↗

Extracellular zinc and ATP restore chloride secretion across cystic fibrosis airway epithelia by triggering calcium entry.Semantic proximity Read ↗

PLCB3 Loss of Function Reduces Pseudomonas aeruginosa-Dependent IL-8 Release in Cystic Fibrosis.Semantic proximity Read ↗

Receptor-mediated activation of CFTR via prostaglandin signaling pathways in the airway.Semantic proximity Read ↗

Activating cystic fibrosis transmembrane conductance regulator channels with pore blocker analogs.Semantic proximity Read ↗

The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients.Semantic proximity Read ↗

Antimicrobial Effects of Ibuprofen Combined with Standard of Care Antimicrobials against Cystic Fibrosis PathogensSemantic proximity Read ↗

Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif.Semantic proximity Read ↗

Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells.Semantic proximity Read ↗

Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents.Semantic proximity Read ↗

CFTR regulation of intracellular calcium in normal and cystic fibrosis human airway epithelia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.