Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Familial clustering of non-nuclear autoantibodies and C3 and C4 complement components in systemic lupus erythematosus.

Arthritis and rheumatism - 1 Apr 2008

Hunnangkul Saowalak, Nitsch Dorothea, Rhodes Benjamin, Chadha Sapna, Roberton Cheri A, Pessôa-Lopes Pedro, Norsworthy Peter J, Fernando Michelle M A, Charles Peter, Mackworth-Young Charles, Isenberg David A, Whittaker John C, Vyse Timothy J

Abstract excerpt

OBJECTIVE: To determine whether key features of systemic lupus erythematosus (SLE), namely, production of non-nuclear antibodies (anti-C1q and anticardiolipin antibodies [aCL]) and depletion of complement components C3 and C4, aggregate in families. In addition, we examined relationships between anti-C1q and C3 and C4 levels. METHODS: The study cohort comprised 1,037 predominantly white (82%) nuclear families in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Cluster Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement C1q

Share to Complement C3

Share to Complement C4

Share to Lupus Erythematosus, Systemic

Share to Odds Ratio

Share to United Kingdom

Source

Identifiers

PMID: 18383369
DOI: 10.1002/art.23400

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Familial clustering of non-nuclear autoantibodies and C3 and C4 complement components in systemic lupus erythematosus.PMID 18383369Read ↗

Familial aggregation and linkage analysis of autoantibody traits in pedigrees multiplex for systemic lupus erythematosus.Semantic proximity Read ↗

A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profileSemantic proximity Read ↗

Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus.Semantic proximity Read ↗

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.Semantic proximity Read ↗

The heritability and genetics of complement C3 expression in UK SLE families.Semantic proximity Read ↗

Familial aggregation of lupus and autoimmunity in an unusual multiplex pedigree.Semantic proximity Read ↗

C1q regulatory region polymorphism down-regulating murine c1q protein levels with linkage to lupus nephritis.Semantic proximity Read ↗

Complete complement deficiency in a large cohort of familial systemic lupus erythematosusSemantic proximity Read ↗

Low copy numbers of complement C4 and homozygous deficiency of C4A may predispose to severe disease and earlier disease onset in patients with systemic lupus erythematosus.Semantic proximity Read ↗

C1q and systemic lupus erythematosus.Semantic proximity Read ↗

Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects.Semantic proximity Read ↗

Hemophilic siblings with chronic hepatitis C: Familial aggregation of spontaneous and treatment-related viral clearance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.