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Article

A high-throughput screening method for small-molecule pharmacologic chaperones of misfolded rhodopsin.

Investigative ophthalmology & visual science - 1 Jul 2008

Noorwez Syed M, Ostrov David A, McDowell J Hugh, Krebs Mark P, Kaushal Shalesh

Abstract excerpt

PURPOSE: Many mutations in rhodopsin, including P23H, result in misfolding and mislocalization of the protein. It has been demonstrated that pharmacologic chaperones are effective in assisting the proper folding and targeting of P23H opsin. This study was designed to investigate a high-throughput screening strategy for identification of pharmacologic chaperones by using a combination of in silico, cell-based, and...

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PMID: 18378578
DOI: 10.1167/iovs.07-1539

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DOCK5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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