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Article

Influence of <i>ABCB1</i> and <i>ABCG2</i> polymorphisms on doxorubicin disposition in Asian breast cancer patients

28 Mar 2008

Abstract excerpt

The influence of three high frequency ABCB1 polymorphisms (c.1236C>T, c.2677G>A/T, and c.3435C>T) and the ABCG2 c.421C>A polymorphism on the disposition of doxorubicin in Asian breast cancer patients receiving adjuvant chemotherapy was investigated in the present study. The allelic frequency of the ABCB1 c.1236T, c.2677T, c.2677A, and c.3435T variants were 60%, 38%, 7%, and 22%, respectively, and the frequency of...

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Identifiers

PMID: 18377430
DOI: 10.1111/j.1349-7006.2008.00744.x

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