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Article

Protein biotinylation visualized by a complex structure of biotin protein ligase with a substrate.

The Journal of biological chemistry - 23 May 2008

Bagautdinov Bagautdin, Matsuura Yoshinori, Bagautdinova Svetlana, Kunishima Naoki

Abstract excerpt

Biotin protein ligase (BPL) catalyzes the biotinylation of the biotin carboxyl carrier protein (BCCP) only at a special lysine residue. Here we report the first structure of BPL.BCCP complex crystals, which are prepared using two BPL mutants: R48A and R48A/K111A. From a detailed structural characterization, it is likely that the mutants retain functionality as enzymes but have a reduced activity to produce the...

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PMID: 18372281
DOI: 10.1074/jbc.M709116200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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