Article
The C-terminal domain of biotin protein ligase from E. coli is required for catalytic activity.
Protein science : a publication of the Protein Society - 1 Dec 2001
Chapman-Smith A, Mulhern T D, Whelan F, Cronan J E, Wallace J C
Abstract excerpt
Biotin protein ligase of Escherichia coli, the BirA protein, catalyses the covalent attachment of the biotin prosthetic group to a specific lysine of the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase. BirA also functions to repress the biotin biosynthetic operon and synthesizes its own corepressor, biotinyl-5'-AMP, the catalytic intermediate in the biotinylation reaction. We have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.