Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice.

Haematologica - 1 May 2008

Liu Sijin, Suragani Rajasekhar N V S, Han Anping, Zhao Wanting, Andrews Nancy C, Chen Jane-Jane

Abstract excerpt

Heme-regulated eIF2alpha kinase (HRI) is essential for regulating globin translation in iron deficiency and in beta-thalassemia. We investigated the role of heme-regulated eIF2alpha kinase in hemoglobin and red blood cell production as well as in iron homeostasis in a mouse model of iron overload...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Cationic Peptides
Share to Bone Morphogenetic Protein 2
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to eIF-2 Kinase

Share to Hemochromatosis

Share to Hepcidins

Share to Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 18367482
DOI: 10.3324/haematol.12175
PMCID: PMC3621076

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18367482-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice.PMID 18367482Read ↗

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency.Semantic proximity Read ↗

Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia.Semantic proximity Read ↗

Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice.Semantic proximity Read ↗

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.Semantic proximity Read ↗

Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels.Semantic proximity Read ↗

Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice.Semantic proximity Read ↗

The N-terminal region of the heme-regulated eIF2alpha kinase is an autonomous heme binding domain.Semantic proximity Read ↗

Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation.Semantic proximity Read ↗

Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6.Semantic proximity Read ↗

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( <i>USF2</i> ) knockout miceSemantic proximity Read ↗

Hepcidin, the recently identified peptide that appears to regulate iron absorption.Semantic proximity Read ↗

First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.