Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The N-terminal region of the heme-regulated eIF2alpha kinase is an autonomous heme binding domain.

European journal of biochemistry - 1 Jan 2000

Uma S, Matts R L, Guo Y, White S, Chen J J

Abstract excerpt

The N-terminal domain (NTD) of the heme-regulated eukaryotic initiation factor (eIF)2alpha kinase (HRI) was aligned to sequences in the NCBI data base using ENTREZ and a PAM250 matrix. Significant similarity was found between amino acids 11-118 in the NTD of rabbit HRI and amino acids 16-120 in mammalian alpha-globins. Several conserved amino acid residues present in globins are conserved in the NTD of HRI. His83...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Galactosidase
Share to Circular Dichroism
Share to eIF-2 Kinase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histidine

Share to Protein Conformation

Share to Rabbits

Share to Recombinant Fusion Proteins

Source

Identifiers

PMID: 10632719
DOI: 10.1046/j.1432-1327.2000.01021.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The N-terminal region of the heme-regulated eIF2alpha kinase is an autonomous heme binding domain.PMID 10632719Read ↗

Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase.Semantic proximity Read ↗

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency.Semantic proximity Read ↗

Elucidation of molecular mechanism of stability of the heme-regulated eIF2α kinase upon binding of its ligand, hemin in its catalytic kinase domain.Semantic proximity Read ↗

Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI.Semantic proximity Read ↗

Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia.Semantic proximity Read ↗

Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice.Semantic proximity Read ↗

Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins.Semantic proximity Read ↗

Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected].Semantic proximity Read ↗

Structural determination of functional units of the nucleotide binding domain (NBD94) of the reticulocyte binding protein Py235 of Plasmodium yoelii.Semantic proximity Read ↗

Spectroscopic studies on human androglobin regulated by its heme distal Gln12 and IQ motif via interaction with calmodulin.Semantic proximity Read ↗

Insights into the architecture of the eIF2Bα/β/δ regulatory subcomplex.Semantic proximity Read ↗

Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.