Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genes of type 2 diabetes in beta cells.

Endocrinology and metabolism clinics of North America - 1 Jun 2006

Trajkovski Mirko, Mziaut Hassan, Schwarz Peter E, Solimena Michele

Abstract excerpt

Type 2 diabetes is a complex polygenic metabolic disorder of epidemic proportions. This review provides a brief overview of the susceptibility genes in type 2 diabetes that primarily affect pancreatic 3 cells, with emphasis on their function and most relevant polymorphisms. We focus on calpain 10, the only susceptibility gene identified thus far through a positional cloning approach in subjects with diabetes.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Insulin-Secreting Cells
Share to Membrane Proteins
Share to Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Tyrosine Phosphatases

Share to Autoantigens

Share to Calpain

Share to Diabetes Mellitus, Type 2

Share to Genetic Predisposition to Disease

Source

Identifiers

PMID: 16632098
DOI: 10.1016/j.ecl.2006.02.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genes of type 2 diabetes in beta cells.PMID 16632098Read ↗

Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene.Semantic proximity Read ↗

Type 2 diabetes candidate gene CAPN10: first, but not last.Semantic proximity Read ↗

Calpain 10 and type 2 diabetes: are we getting closer to an explanation?Semantic proximity Read ↗

Genetics of type 2 diabetes mellitus: status and perspectives.Semantic proximity Read ↗

Calpain 10 and genetics of type 2 diabetes.Semantic proximity Read ↗

Linkage of calpain 10 to type 2 diabetes: the biological rationale.Semantic proximity Read ↗

[Calpain 10 as a susceptibility gene of type 2 diabetes].Semantic proximity Read ↗

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.Semantic proximity Read ↗

Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.Semantic proximity Read ↗

Pathomechanisms of type 2 diabetes genes.Semantic proximity Read ↗

Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes.Semantic proximity Read ↗

[Type 2 diabetes and genetic variations of calpain 10 gene].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.