Article
Stability analysis of mixtures of mutagenetic trees.
BMC bioinformatics - 26 Mar 2008
Bogojeska Jasmina, Lengauer Thomas, Rahnenführer Jörg
Abstract excerpt
BACKGROUND: Mixture models of mutagenetic trees are evolutionary models that capture several pathways of ordered accumulation of genetic events observed in different subsets of patients. They were used to model HIV progression by accumulation of resistance mutations in the viral genome under drug pressure and cancer progression by accumulation of chromosomal aberrations in tumor cells. From the mixture models a...
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