Maximum likelihood estimation of oncogenetic tree models

Abstract excerpt

We present a new approach for modelling the dependences between genetic changes in human tumours. In solid tumours, data on genetic alterations are usually only available at a single point in time, allowing no direct insight into the sequential order of genetic events. In our approach, genetic tumour development and progression is assumed to follow a probabilistic tree model. We show how maximum likelihood...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bioinformatics and Genomic Networks
• Share to Cancer Genomics and Diagnostics
• Share to Genetic factors in colorectal cancer