Article
Suppressor T-cell levels are unreliable indicators of the impaired immune response following thermal injury.
The Journal of trauma - 1 Jun 1992
Gough D B, Jordan A, Collins K, Mannick J A, Rodrick M L
Abstract excerpt
The presence of increased levels of suppressor T cells after thermal injury and their relevance remain controversial. It is unclear whether suppressor T cells are the cause or result of sepsis complicating thermal injury. Spleen cells from a standardized murine burn model and sham burn controls were studied and the relationship between the levels of suppressor cytotoxic T cells (CD8, Lyt-2+), helper T cells (CD4,...
Topics
- Animals
- Antibodies, Monoclonal
- Biomarkers
- Burns
- CD4-CD8 Ratio
- Concanavalin A
- Disease Models, Animal
- Evaluation Studies as Topic
- Immunologic Deficiency Syndromes
- Infections
- Interleukin-2