Article
CD8+ T cell loss induces autoinflammation in inborn errors of cell death.
Nature communications - 11 Mar 2026
Dai Jialin, Jin Taijie, Su Gaixiu, Han Xu, Wang Jun, Liu Chenlu, Zheng Wenjie, Zhang Qiuye, Zhang Ranran, Kuehn Hye Sun, Yang Jun, Guo Li, Zhang Dan, Li Ming, Xu Yingjie, Yue Tong, Wen Min, Zhu Jia, Kang Min, Lai Jianming, Wu Feifei, Wang Shihao, Zhang Jiahui, Aksentijevich Ivona, Rosenzweig Sergio D, Lee Pui Y, Yuan Junying, Yu Xiaomin, Zhou Qing
Abstract excerpt
Systemic autoinflammatory diseases (SAID) with inborn errors of cell death (IECD) are caused by overactivation of programmed cell death (PCD). However, the pathogenesis by which PCD leads to autoinflammation remains unclear. Here, we identified IECD patients carrying compound heterozygous RIPK1 variants K377E/R390G with autoinflammatory manifestations. Mechanistically, K377E and R390G mutations suppress NF-κB...
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