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Induction of NKG2D Ligands by Gamma Radiation and Tumor Necrosis Factor-α May Participate in the Tissue Damage During Acute Graft-Versus-Host Disease

27 Mar 2008

Abstract excerpt

Immunopathology of acute graft-versus-host disease (aGVHD) involves secretion of proinflammatory cytokines with subsequent expression of danger signals by injured host tissues. This explanation, however, does not explain the cluster of aGVHD target organs (skin, gut, and liver). NKG2D ligands (MICA/B and ULBP1-3 proteins) are stress-induced molecules that act as danger signals to alert NK and alphabeta or...

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PMID: 18360276
DOI: 10.1097/tp.0b013e31816691ef

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