Article
Characterisation of CD154+ T cells following ex vivo birch allergen stimulation defines a close relationship between T cell subsets in healthy volunteers.
BMC immunology - 22 Mar 2013
Smith Karen A, Gray Nicola J, Cheek Elizabeth, Saleh Femi, Lavender Jo, Frew Anthony J, Kern Florian, Tarzi Michael D
Abstract excerpt
BACKGROUND: Allergic sensitisation has been ascribed to a dysregulated relationship between allergen-specific Th1, Th2 and regulatory T cells. We hypothesised that the relationship between these T cell subsets could be better defined using a short-term allergen stimulation system followed by direct analysis of CD154-positive T cells. Using peripheral blood samples from birch pollinosis patients and healthy...
Topics
- Adult
- Allergens
- Betula
- CD40 Ligand
- Cell Differentiation
- Cytokines
- Epitopes
- Female
- Health
- Humans
- Immune Tolerance