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Article

Lys40 but not Arg143 influences selectivity of angiotensin conversion by human alpha-chymase.

Biochimica et biophysica acta - 29 Apr 2002

Muilenburg Diego J, Raymond Wilfred W, Wolters Paul J, Caughey George H

Abstract excerpt

Human alpha-chymase is an efficient angiotensin (AT) converting enzyme, selectively hydrolyzing AT I at Phe8 to generate bioactive AT II, which can promote cardiac hypertrophy, vascular stenosis, and hypertension. Some related enzymes, such as rat beta-chymase 1, are much less selective, destroying AT by cleaving at Tyr4. Comparisons of chymase structure and activity led to speculation that interaction between AT...

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PMID: 12007614
DOI: 10.1016/s0167-4838(02)00224-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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