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Article

Hereditary hyperuricemia and renal disease.

Seminars in nephrology - 1 Jan 2005

Cameron J Stewart, Simmonds H Anne

Abstract excerpt

Hyperuricemia and gout have long been known to run in families. As well as an apparently multifactorial genetic component to classic gout itself, 2 rather unusual sex-linked single-gene disorders of purine biosynthesis or recycling have been defined: deficiency of the enzyme hypoxanthine-guaninephosphoribosyl transferase (HPRT), and overactivity of PPriboseP synthase. Both result in overproduction of urate,...

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Source

Identifiers

PMID: 15660329
DOI: 10.1016/j.semnephrol.2004.09.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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