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Article

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility.

Genome research - 1 May 2008

Keller Mark P, Choi YounJeong, Wang Ping, Davis Dawn Belt, Rabaglia Mary E, Oler Angie T, Stapleton Donald S, Argmann Carmen, Schueler Kathy L, Edwards Steve, Steinberg H Adam, Chaibub Neto Elias, Kleinhanz Robert, Turner Scott, Hellerstein Marc K, Schadt Eric E, Yandell Brian S, Kendziorski Christina, Attie Alan D

Abstract excerpt

Insulin resistance is necessary but not sufficient for the development of type 2 diabetes. Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by increasing insulin production through an expansion of beta-cell mass or increased insulin secretion. Communication between insulin target tissues and beta-cells may initiate this compensatory response. Correlated changes in gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18347327
DOI: 10.1101/gr.074914.107
PMCID: PMC2336811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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