Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions.

The Journal of experimental medicine - 14 Apr 2008

Majumder Parimal, Gomez Jorge A, Chadwick Brian P, Boss Jeremy M

Abstract excerpt

Knockdown of the insulator factor CCCTC binding factor (CTCF), which binds XL9, an intergenic element located between HLA-DRB1 and HLA-DQA1, was found to diminish expression of these genes. The mechanism involved interactions between CTCF and class II transactivator (CIITA), the master regulator...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCCTC-Binding Factor
Share to Chromatin
Share to HLA-DQ alpha-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DQ Antigens

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to Interferon-gamma

Share to Regulatory Factor X Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 18347100
DOI: 10.1084/jem.20071843
PMCID: PMC2292219

Genes

CTCF
CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18347100-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions.PMID 18347100Read ↗

A super enhancer controls expression and chromatin architecture within the MHC class II locus.Semantic proximity Read ↗

The protein CTCF is required for the enhancer blocking activity of vertebrate insulators.Semantic proximity Read ↗

CTCF Interacts with and Recruits the Largest Subunit of RNA Polymerase II to CTCF Target Sites Genome-WideSemantic proximity Read ↗

Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA.Semantic proximity Read ↗

CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.Semantic proximity Read ↗

Vigilin interacts with CTCF and is involved in the maintenance of imprinting of IGF2 through a novel RNA-mediated mechanism.Semantic proximity Read ↗

Epigenomic regulation of human T-cell leukemia virus by chromatin-insulator CTCF.Semantic proximity Read ↗

Transgenic RNAi Reveals Essential Function for CTCF in <i>H19</i> Gene ImprintingSemantic proximity Read ↗

CTCF mediates insulator function at the <i>CFTR</i> locusSemantic proximity Read ↗

CCAAT Promoter element regulates transgenerational expression of the MHC class I gene.Semantic proximity Read ↗

Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells.Semantic proximity Read ↗

Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.