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Article

Beta-amyloid deposition in brains of subjects with diabetes.

Neuropathology and applied neurobiology - 1 Feb 2009

Alafuzoff I, Aho L, Helisalmi S, Mannermaa A, Soininen H

Abstract excerpt

AIM: A causative association between diabetes mellitus (DM) and Alzheimer's disease (AD) has been suggested based on clinical and epidemiological studies. One hypothesis is that the link between DM and AD is related to the function of insulin-degrading enzyme (IDE), an enzyme that degrades not only insulin and pancreatic amylin but also beta-amyloid (Abeta). Thus, in diabetics, insulin and Abeta might compete for...

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Share to Amyloid beta-Peptides
Share to Brain Infarction
Share to Cerebral Amyloid Angiopathy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18346114
DOI: 10.1111/j.1365-2990.2008.00948.x

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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