Article
A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome.
Molecular pharmacology - 1 Jul 2006
Achanta Geetha, Modzelewska Aneta, Feng Li, Khan Saeed R, Huang Peng
Abstract excerpt
Chalcones and their derivatives have been shown to have potent anticancer activity. However, the exact mechanisms of cytotoxic activity remain to be established. In this study, we have evaluated a series of boronic chalcones for their anticancer activity and mechanisms of action. Among the eight chalcone derivatives tested, 3,5-bis-(4-boronic acid-benzylidene)-1-methyl-piperidin-4-one (AM114) exhibited most...
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