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Article

HSPA5 promoter polymorphisms and risk of Parkinson's disease in Taiwan.

Neuroscience letters - 25 Apr 2008

Chen Chiung-Mei, Wu Yih-Ru, Hu Fen-Ju, Chen Yi-Chun, Chuang Tzu-Jung, Cheng Ya-Fen, Lee-Chen Guey-Jen

Abstract excerpt

Endoplasmic reticulum (ER) stress induced by misfolded proteins has been implicated in Parkinson's disease (PD) pathogenesis. A malfunction of unfolded protein response (UPR) to ER stress can result in PD as well as other neurodegenerative diseases. Heat shock 70 kDa protein 5 (HSPA5) is one of the UPR chaperones reactive to ER stress to block the apoptotic process. HSPA5 promoter polymorphisms -415 G/A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18343577
DOI: 10.1016/j.neulet.2008.02.039

Genes

HSPA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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