Article
Promoter polymorphisms modulating HSPA5 expression may increase susceptibility to Taiwanese Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Nov 2008
Hsu W-C, Wang H-K, Lee L-C, Fung H-C, Lin J-C, Hsu H-P, Wu Y-R, Ro L-S, Hu F-J, Chang Y-T, Lee-Chen G-J, Chen C-M
Abstract excerpt
Endoplasmic reticulum (ER) chaperone heat shock 70 kDa protein 5 (HSPA5/GRP78) is known to be involved in the metabolism of amyloid precursor protein and neuronal death in Alzheimer's disease (AD) could arise from dysfunction of the ER. Through a case-control study and an expression assay, we investigated the association of HSPA5 -415 G/A (rs391957), -370 C/T (rs17840761) and -180 del/G (rs3216733) polymorphisms...
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