Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.

doi:10.1016/j.neurobiolaging.2021.06.011

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Article

Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.

Neurobiology of aging - 1 Nov 2021

Wang Hung-Li, Yeh Tu-Hsueh, Huang Ying-Zu, Weng Yi-Hsin, Chen Rou-Shayn, Lu Chin-Song, Wei Kuo-Chen, Liu Yu-Chuan, Chen Ying-Ling, Chen Chao-Lang, Chen Yu-Jie, Lin Yan-Wei, Hsu Chia-Chen, Chiu Chi-Han, Chiu Ching-Chi

Abstract excerpt

Our previous study suggests that upregulated RAB35 is implicated in etiology of Parkinson's disease (PD). We hypothesized that upregulated RAB35 results from single nucleotide polymorphisms (SNPs) in RAB35 gene promoter. We identified SNPs within RAB35 gene promoter by analyzing DNA samples of discovery cohort and validation cohort. SNP rs17525453 within RAB35 gene promoter (T>C at position of -66) was...

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PMID: 34275689
DOI: 10.1016/j.neurobiolaging.2021.06.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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