Temperature-induced switch to the pathogenic yeast form of <i>Histoplasma capsulatum</i> requires Ryp1, a conserved transcriptional regulator

Abstract excerpt

Histoplasma capsulatum, a fungal pathogen of humans, switches from a filamentous spore-forming mold in the soil to a pathogenic budding-yeast form in the human host. This morphologic switch, which is exhibited by H. capsulatum and a group of evolutionarily related fungal pathogens, is regulated by temperature. Using insertional mutagenesis, we identified a gene, RYP1 (required for yeast phase growth), which is...