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Rapid genotyping of known mutations and polymorphisms in beta-globin gene based on the DHPLC profile patterns of homoduplexes and heteroduplexes.

Clinical biochemistry - 1 Jun 2008

Li Qiang, Li Li-Yan, Huang Sheng-Wen, Li Liang, Chen Xiao-Wei, Zhou Wan-Jun, Xu Xiang-Min

Abstract excerpt

BACKGROUND: Beta-thalassemia represents a great heterogeneity as over 200 mutations have been identified for the beta-globin gene responsible for this disease. A rapid genotyping test with high accuracy, selectivity, and reproducibility suitable for the determination of known mutations is needed for prenatal screening and post-natal diagnosis of this disease in clinical setting. DESIGN AND METHODS: We have...

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Identifiers

PMID: 18339318
DOI: 10.1016/j.clinbiochem.2008.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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