Article
Setup of a Protocol of Molecular Diagnosis of β-Thalassemia Mutations in Tunisia using Denaturing High-Performance Liquid Chromatography (DHPLC).
Journal of clinical laboratory analysis - 1 Sept 2016
Sahli Chaima Abdelhafidh, Ben Salem Ikbel, Jouini Latifa, Laouini Naouel, Dabboubi Rym, Hadj Fredj Sondes, Siala Hajer, Othmeni Rym, Dakhlaoui Boutheina, Fattoum Slaheddine, Bibi Amina, Messaoud Taieb
Abstract excerpt
BACKGROUNDS: β-Thalassemia is one of the most prevalent worldwide autosomal recessive disorders. It presents a great molecular heterogeneity resulting from more than 200 causative mutations in the β-globin gene. In Tunisia, β-thalassemia represents the most prevalent monogenic hemoglobin disorder with 2.21% of carriers. Efficient and reliable mutation-screening methods are essential in order to establish...
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