Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Accurate and rapid prenatal diagnosis of beta-thalassemia by a multiplex primer extension and denaturing high-performance liquid chromatography technique].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Dec 2004

Hua Liang, Zhu Hai, Li Xin-rong, Li Jian, Mo Qiu-hua, Liao Can, Hou Yun-xia, Zhong Mei, Xu Xiang-min

Abstract excerpt

OBJECTIVE: To develop a primer-extension in combination with denaturing high-performance liquid chromatography (PE-DHPLC)-based assay for prenatal diagnosis of the five most common beta-thalassemia mutations in Chinese. METHODS: The human beta-globin gene fragment was amplified by PCR, followed by a multiple PE reaction specific for each five mutations. Then the PE product mixtures were separated for genotyping...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Thalassemia
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Fetal Diseases

Share to Globins

Share to Point Mutation

Share to Pregnancy

Share to Prenatal Diagnosis

Source

Identifiers

PMID: 15583991

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Accurate and rapid prenatal diagnosis of beta-thalassemia by a multiplex primer extension and denaturing high-performance liquid chromatography technique].PMID 15583991Read ↗

Rapid, accurate genotyping of beta-thalassaemia mutations using a novel multiplex primer extension/denaturing high-performance liquid chromatography assay.Semantic proximity Read ↗

Rapid genotyping of known mutations and polymorphisms in beta-globin gene based on the DHPLC profile patterns of homoduplexes and heteroduplexes.Semantic proximity Read ↗

Birth of healthy children after preimplantation diagnosis of beta-thalassemia by whole-genome amplification.Semantic proximity Read ↗

[Detection of common deletions and mutations causing α-thalassemia in Southeast Asians and Southern Chinese with denaturing high performance liquid chromatography].Semantic proximity Read ↗

Prenatal diagnosis of β-thalassemia in Guangxi Zhuang Autonomous Region, China.Semantic proximity Read ↗

[Rapid prenatal diagnosis of 60 cases with beta-thalassemia by reverse dot blot analysis].Semantic proximity Read ↗

Novel multiplex primer extension and denaturing high-performance liquid chromatography for genotyping of the deafness gene mutations.Semantic proximity Read ↗

[Molecular and prenatal diagnosis for a Chinese pregnant woman with a novel mutation of β thalassemia].Semantic proximity Read ↗

[Analysis of haematological phenotype and mutation spectrum of δ-globin gene from Guangdong area in Chinese Han prenatal population].Semantic proximity Read ↗

Prenatal Diagnosis of β-Thalassemia by Reverse Dot-Blot Hybridization in Southern ChinaSemantic proximity Read ↗

[Phenotyping and genotyping studies in a family with the compound heterozygosity for a deletional delta beta-thalassemia and a beta-thalassemia].Semantic proximity Read ↗

[Successful preimplantation genetic diagnosis for beta-thalassemia using multiplex nested polymerase chain reaction].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.