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Article

Regional vulnerability in Huntington's disease: fMRI-guided molecular analysis in patients and a mouse model of disease.

Neurobiology of disease - 1 Apr 2013

Lewandowski Nicole M, Bordelon Yvette, Brickman Adam M, Angulo Sergio, Khan Usman, Muraskin Jordan, Griffith Erica Y, Wasserman Paula, Menalled Liliana, Vonsattel Jean Paul, Marder Karen, Small Scott A, Moreno Herman

Abstract excerpt

Although the huntingtin gene is expressed in brain throughout life, phenotypically Huntington's disease (HD) begins only in midlife and affects specific brain regions. Here, to investigate regional vulnerability in the disease, we used functional magnetic resonance imaging (fMRI) to translationally link studies in patients with a mouse model of disease. Using fMRI, we mapped cerebral blood volume (CBV) in three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23220414
DOI: 10.1016/j.nbd.2012.11.014
PMCID: PMC4435974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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