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Article

Regional cortical thinning in preclinical Huntington disease and its relationship to cognition.

Neurology - 13 Sept 2005

Rosas H D, Hevelone N D, Zaleta A K, Greve D N, Salat D H, Fischl B

Abstract excerpt

The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.

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Source

Identifiers

PMID: 16157910
DOI: 10.1212/01.wnl.0000174432.87383.87

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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