Article

Relating quantitative 7T MRI across cortical depths to cytoarchitectonics, gene expression and connectomics: a framework for tracking neurodegenerative disease

2020-02-05

Abstract excerpt

Cortical layer-specific ultra-high field MRI has the potential to provide anatomically precise biomarkers and mechanistic insights into neurodegenerative disease. Here we compare cortical layer-specificity for a 7T multi-parametric mapping (MPM) 500μm whole brain acquisition to the von Economo and Big Brain post-mortem histology atlases. We also investigate the relationship between 7T MPMs, layer-specific gene exp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7a4c1818-150e-5414-8bd5-2022f1802166
DOI: 10.1101/2020.02.05.935080

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Relating quantitative 7T MRI across cortical depths to cytoarchitectonics, gene expression and connectomics: a framework for tracking neurodegenerative diseaseDOI 10.1101/2020.02.05.935080Read

Relating quantitative 7T MRI across cortical depths to cytoarchitectonics, gene expression and connectomicsSemantic proximity Read

A molecular map of the living human brain from quantitative MRISemantic proximity Read

Genetic architecture of the white matter connectome of the human brainSemantic proximity Read

Mapping the Microstructure of Human Cerebral Cortex In Vivo with Diffusion MRISemantic proximity Read

Quantitative MRI maps of human neocortex explored using cell type-specific gene expression analysisSemantic proximity Read

The spatial arrangement of laminar thickness profiles in the human cortex scaffolds processing hierarchySemantic proximity Read

Longitudinal development of the human white matter structural connectome and its association with brain transcriptomic and cellular architectureSemantic proximity Read

Brain wiring and supragranular-enriched genes linked to protracted human frontal cortex developmentSemantic proximity Read

Genetic Insights into Brain Morphology: a Genome-Wide Association Study of Cortical Thickness and T1-Weighted MRI Gray Matter-White Matter Intensity ContrastSemantic proximity Read

Structural covariance networks are coupled to expression of genes enriched in supragranular layers of the human cortexSemantic proximity Read

Visualizing cortical laminar architecture in the living human brain using next-generation ultra-high-gradient diffusion MRISemantic proximity Read