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IL-22-STAT3 Pathway Plays a Key Role in the Maintenance of Ileal Homeostasis in Mice Lacking Secreted Mucus Barrier

30 Jan 2015

Abstract excerpt

BACKGROUND: Muc2-deficient mice show no signs of ileal pathology but the mechanisms remained unknown. METHODS: Wild-type (WT), Muc2, and Muc2 mice were killed at 2, 4, and 8 weeks of age. Total RNA from ileum was used for full genome transcriptome analysis and qPCR. Microbiota composition was determined using a mouse intestinal chip (MITChip). Morphological and immunohistological studies were performed on...

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PMID: 25636123
DOI: 10.1097/mib.0000000000000319

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