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Article

Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.

Science (New York, N.Y.) - 7 Nov 2003

Yu Xianghui, Yu Yunkai, Liu Bindong, Luo Kun, Kong Wei, Mao Panyong, Yu Xiao-Fang

Abstract excerpt

Human immunodeficiency virus-1 (HIV-1) Vif is essential for viral evasion of host antiviral factor CEM15/APOBEC3G. We report that Vif interacts with cellular proteins Cul5, elongins B and C, and Rbx1 to form an Skp1-cullin-F-box (SCF)-like complex. The ability of Vif to suppress antiviral activit...

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Source

Identifiers

PMID: 14564014
DOI: 10.1126/science.1089591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14564014-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.PMID 14564014Read ↗

Vif overcomes the innate antiviral activity of APOBEC3G by promoting its degradation in the ubiquitin-proteasome pathway.Semantic proximity Read ↗

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