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Article

Bendamustine is effective in p53-deficient B-cell neoplasms and requires oxidative stress and caspase-independent signaling.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2008

Roué Gaël, López-Guerra Mónica, Milpied Pierre, Pérez-Galán Patricia, Villamor Neus, Montserrat Emili, Campo Elias, Colomer Dolors

Abstract excerpt

PURPOSE: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are two incurable B-cell lymphoid neoplasms characterized by distinct clinical presentation and evolution. Bendamustine hydrochloride is a multifunctional, alkylating agent with a purine-like ring system that exhibits acti...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, p53

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

Identifiers

PMID: 18980985
DOI: 10.1158/1078-0432.CCR-08-0388

Genes

BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18980985-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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