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Article

Bendamustine is effective in p53-deficient B-cell neoplasms and requires oxidative stress and caspase-independent signaling.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2008

Roué Gaël, López-Guerra Mónica, Milpied Pierre, Pérez-Galán Patricia, Villamor Neus, Montserrat Emili, Campo Elias, Colomer Dolors

Abstract excerpt

PURPOSE: Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are two incurable B-cell lymphoid neoplasms characterized by distinct clinical presentation and evolution. Bendamustine hydrochloride is a multifunctional, alkylating agent with a purine-like ring system that exhibits activity in multiple cancer models, including CLL and MCL, but whose mechanism is only partially described. Our aim was to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Genes, p53

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Lymphoma, Mantle-Cell

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Source

Identifiers

PMID: 18980985
DOI: 10.1158/1078-0432.CCR-08-0388

Genes

BAX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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