Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response.

Experimental hematology - 1 Oct 2007

Lagneaux Laurence, Gillet Nicolas, Stamatopoulos Basile, Delforge Alain, Dejeneffe Marielle, Massy Martine, Meuleman Nathalie, Kentos Alain, Martiat Philippe, Willems Luc, Bron Dominique

Abstract excerpt

OBJECTIVE: Chronic lymphocytic leukemia (CLL) cells develop chemoresistance over time associated with defects in apoptosis pathway. Novel treatment strategies are required to overcome resistance of cells to commonly used agents. The effects of valproic acid (VPA), an antiepileptic drug with histone deacetylase inhibitory activity, on mononuclear cells isolated from 40 CLL patients were evaluated. METHODS: CLL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 8
Share to DNA Fragmentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Screening Assays, Antitumor

Share to Gene Expression Regulation, Leukemic

Share to Histone Deacetylase Inhibitors

Share to Phosphatidylserines

Share to TNF-Related Apoptosis-Inducing Ligand

Share to Valproic Acid

Source

Identifiers

PMID: 17697742
DOI: 10.1016/j.exphem.2007.06.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response.PMID 17697742Read ↗

Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and -independent apoptotic signaling pathwaysSemantic proximity Read ↗

Selective inhibition of PED protein expression sensitizes B‐cell chronic lymphocytic leukaemia cells to TRAIL‐induced apoptosisSemantic proximity Read ↗

A Novel Paradigm to Trigger Apoptosis in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

The role and possible molecular mechanism of valproic acid in the growth of MCF-7 breast cancer cellsSemantic proximity Read ↗

The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Carfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses.Semantic proximity Read ↗

Therapeutic targeting of chronic lymphocytic leukemia by silver nanoparticlesSemantic proximity Read ↗

Bendamustine is effective in p53-deficient B-cell neoplasms and requires oxidative stress and caspase-independent signaling.Semantic proximity Read ↗

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanismSemantic proximity Read ↗

Apoptosis of B-cell chronic lymphocytic leukemia cells induced by a novel BH3 peptidomimeticSemantic proximity Read ↗

Verbena officinalis essential oil and its component citral as apoptotic-inducing agent in chronic lymphocytic leukemia.Semantic proximity Read ↗

Could valproic acid be an effective anticancer agent? The evidence so farSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.