Article
Exome sequencing identifies DLG1 as a novel gene for potential susceptibility to Crohn's disease in a Chinese family study.
PloS one - 1 Jan 2014
Xu Shufang, Zhou Feng, Tao Jinsheng, Song Lu, Ng Siew Chien, Wang Xiaobing, Chen Liping, Yi Fengming, Ran Zhihua, Zhou Rui, Xia Bing
Abstract excerpt
BACKGROUND: Genetic variants make some contributions to inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). More than 100 susceptibility loci were identified in Western IBD studies, but susceptibility gene has not been found in Chinese IBD patients till now. Sequencing of individuals with an IBD family history is a powerful approach toward our understanding of the...
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